Effect of inhibition of oxygen free radical
نویسنده
چکیده
The potential role of oxygen free radicals in hCG-induced ovulation was investigated using the free radical scavenging enzymes superoxide dismutase (SOD) and/or catalase with the in-vitro perfused rabbit ovary preparation. SOD (25 \g=m\g/ml) and SOD + catalase (25 \g=m\g/ml)significantly reduced the % of large follicles that ovulated during perfusion (P < 0\m=.\005).Neither maturity nor degeneration of ovulated ova and follicular oocytes was affected by SOD and/or catalase. Progesterone concentration in the perfusate was significantly increased in the SOD + catalase treatment group (P < 0\m=.\01).These results indicate a significant role for oxygen free radicals in the process of ovulation.
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